Transcriptomics

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Single-cell RNA-sequencing of CD44+ CD4+ T cells from day 21 post-LCMV Cl13 infection following transient CD4+ T cell depletion (scRNA-Seq)


ABSTRACT: CD4+ T cells play a critical role in sustaining the effector function of CD8+ T cells during chronic viral infection. When CD4+ T cell “help” is absent, following transient CD4+ T cell depletion, CD8+ T cells enter a dysfunctional state, losing their capacity for viral control. Here, we applied scRNA-seq to determine the CD4+ T cell subsets that repopulate following transient CD4+ T cell depletion, during LCMV Clone 13 infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE200721 | GEO | 2022/11/29

REPOSITORIES: GEO

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