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Effect of Pak4 deficiency on transcriptome in liver of mice

ABSTRACT: PAK4 has emerged as a promising target for anti-cancer drug development. However, its role in oxidative stress conditions remains elusive. We investigated the effects of PAK4 signaling on hepatic ischemia/reperfusion (I/R) injury. To elucidate molecular mechanisms, we performed RNA-sequencing analysis using littermate WT and hepatocyte-specific Pak4 KO mice in I/R condition. Transcriptomic analysis enabled us to find the main signaling nodes altered by Pak4 deficiency in close association with antioxidant response.

ORGANISM(S): Mus musculus

PROVIDER: GSE200913 | GEO | 2022/04/20

REPOSITORIES: GEO

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