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Effects of acute maximal exercise and high-fat feeding on the mouse skeletal muscle transcriptome

ABSTRACT: Physical inactivity and over-nutrition are key risk factors for metabolic diseases, with impaired skeletal muscle gene transcription and metabolic function proposed as key etiological factors. Here, we have used RNA-seq to assessed the skeletal muscle transcriptome from mice fed a control or high fat diet (HFD), both pre- and 3h post-exercise. HFD up-regulated genes involved in lipid catabolism in skeletal muscle (quadriceps), while decreasing 241 exercise-responsive genes related to skeletal muscle plasticity. Collectively, this experimental approach provides a suitable resource to study transcriptional and metabolic networks in skeletal muscle in the context of health and disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE97718 | GEO | 2017/10/31

SECONDARY ACCESSION(S): PRJNA382720

REPOSITORIES: GEO

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