Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TRAP-seq of samples isolated from DHPG-stimulated WT and Fmr1-/y hippocampal slices

ABSTRACT: Sequencing files from TRAP-seq samples isolated from DHPG-stimulated WT and Fmr1-/y hippocampal slices

ORGANISM(S): Mus musculus

PROVIDER: GSE201239 | GEO | 2022/06/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

CX DHPG TRAP-seq

Project description:Sequencing files from TRAP-seq samples isolated from DHPG-stimulated WT and Fmr1-/y hippocampal slices incubated with vehicle or 200 nM CX-5461

2022-06-07 | GSE200919 | GEO

TRAP-seq of samples isolated from DHPG-stimulated WT and Fmr1-/y hippocampal slices

Project description:TRAP-seq of samples isolated from DHPG-stimulated WT and Fmr1-/y hippocampal slices

| PRJNA830479 | ENA

TRAP from CA1 pyramidal neurons and cerebellar granule cells in Fmr1 KO and wildtype mice

Project description:TRAP (translating ribosome affinity purification) from CA1 pyramidal neurons and cerebellar granule cells in wildtype and Fmr1 KO littermate pairs. These data show a global downregulation of FMRP targets in Fmr1 KO mice in these cell types.

2020-01-07 | GSE127845 | GEO

RNA sequencing data of Wild Type and Fmr1 KO hippocampal neuron

Project description:Fragile X syndrome (FXS), caused by mutations in fragile X mental retardation 1 gene (FMR1), is a prevailing genetic disorder of intellectual disability and autism. Analysis of transcriptome outcome (differentially expressed genes between WT and Fmr1 KO hippocampal neuron) associated with FXS reveal promising value of gene signature-based computation in repurposing drugs for potential practical treatment.

2019-12-05 | GSE114015 | GEO

Transcription profiling of mouse hippocampal slices after NMDA or forskolin-rolipram-0 Mg2+ or bicuculline treatment

Project description:Effect of different chemical stimuli (NMDA(N-methyl-D-aspartic acid), forskolin/rolipram/0 Mg, bicuculline) on gene expression after 1 h of stimulation in hippocampal slices

2008-06-01 | E-MEXP-1184 | biostudies-arrayexpress

Ribosome profiling and RNA-seq of Tsc2+/- hippocampal slices

Project description:Ribosome profiling and RNA-seq of Tsc2+/- hippocampal slices

| PRJNA603987 | ENA

Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function

Project description:Fragile X Syndrome (FXS) is the most common cause of inherited intellectual disabilities and the most prevalent monogenic cause of autism. Although the knockout (KO) of the Fmr1 gene homolog in mice is primarily used for elucidating the neurobiological substrate of FXS, there is limited association of the experimental data with the pathophysiological condition in humans. The use of Fmr1 KO rats offers additional translational validity in this regard. Therefore, we employed a multi-level approach to study the behavioral profile and the glutamatergic and GABAergic neurotransmission status in pathophysiology-associated brain structures of Fmr1 KO rats, including the recordings of evoked and spontaneous field potentials from hippocampal slices, paralleled with next-generation RNA sequencing (RNA-seq). We found that these rats exhibit hyperactivity and cognitive deficits, along with characteristic bidirectional glutamatergic and GABAergic alterations in the prefrontal cortex and the hippocampus. These results are coupled to affected excitability and local inhibitory processes in the hippocampus, along with a specific transcriptional profile, highlighting dysregulated hippocampal network activity in KO rats. Overall, our data provide novel insights concerning the biobehavioral profile of FmR1 KO rats and translationally upscales our understanding on pathophysiology and symptomatology of FXS syndrome.

2023-12-31 | GSE248950 | GEO

Expression data from rat organotypic hippocampal slices lentivirally infected with shRNF10 or scramble construct

Project description:RNF10 is a synapse-to-nucleus protein messsenger regulating NMDAR-dependent gene trascription. We have charaterized the impact of the absence of RNF10 on structural synaptic plasticity. In this dataset we included expression data from homogenates of DIV14 rat organotypic hippocampal slices lentivirally infected with shRNF10 or scramble construct 8 total samples were analyzed (4 shRNF10 and 4 scramble).

2015-06-20 | E-GEOD-69267 | biostudies-arrayexpress

Expression data from rat organotypic hippocampal slices lentivirally infected with shRNF10 or scramble construct

2015-06-20 | GSE69267 | GEO

Ribosome profiling and RNA-seq of wild-type hippocampal slices

Project description:Ribosome profiling and RNA-seq of wild-type hippocampal slices

| PRJNA666888 | ENA