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PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE201518 | GEO | 2022/07/20

REPOSITORIES: GEO

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PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity [RNA-Seq]

Project description:The extracellular activity of Plasminogen activator inhibitor-1 (PAI-1) is well described, acting as an inhibitor of tissue plasminogen activator and urokinase-type plasminogen activator, impacting fibrinolysis. Recent studies have revealed a pro-tumorigenic role of PAI-1 in human cancers, via the regulation of angiogenesis and tumor cell survival. In this study, immunohistochemical staining of 939 human bladder cancer specimens showed that PAI-1 expression levels correlated with tumor grade, tumor stage and overall survival. The typical subcellular localization of PAI-1 is cytoplasmic, but in approximately a quarter of the cases, PAI-1 was observed to be localized to both the tumor cell cytoplasm and the nucleus. To investigate the potential function of nuclear PAI-1 in tumor biology we applied chromatin immunoprecipitation (ChIP)-sequencing, gene expression profiling, and rapid immunoprecipitation mass spectrometry to a pair of bladder cancer cell lines. ChIP-sequencing revealed that PAI-1 can bind DNA at distal intergenic regions, suggesting a role as a transcriptional coregulator. The downregulation of PAI-1 in bladder cancer cell lines caused the upregulation of numerous genes, and the integration of ChIP-sequence and RNA-sequence data identified 57 candidate genes subject to PAI-1 regulation. Taken together, the data suggest that nuclear PAI-1 can influence gene expression programs and support malignancy.

2022-07-20 | GSE201517 | GEO

PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity [ChIP-Seq]

2022-07-20 | GSE201515 | GEO

Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model.

Project description: Not available

| S-EPMC7003426 | biostudies-literature

Potential Roles of IGF2BP3 in Bladder Cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-27 | GSE171024 | GEO

Identification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-01-06 | E-GEOD-66760 | biostudies-arrayexpress

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-03 | E-GEOD-37817 | biostudies-arrayexpress

The pattern of genomic instability during bladder cancer progression

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-01 | E-GEOD-50668 | biostudies-arrayexpress

The UBC-40 Urothelial Bladder Cancer Cell Line Index

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-06-19 | E-GEOD-64573 | biostudies-arrayexpress

Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila.

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-17 | GSE222717 | GEO

Profiling of bladder cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

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