Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression analysis of lymphoblast cells lines in Parkinson's disease

ABSTRACT: Genome-wide transcriptome analysis of expression changes in EBV transformed cell lines from the Coriell Cell Repository in Parkinson and Control subjects.

ORGANISM(S): Homo sapiens

PROVIDER: GSE20153 | GEO | 2010/02/04

SECONDARY ACCESSION(S): PRJNA125581

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression analysis of lymphoblast cells lines in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in EBV transformed cell lines from the Coriell Cell Repository in Parkinson and Control subjects. 8 Parkinson cell lines versus 8 control cell lines.

2010-02-22 | E-GEOD-20153 | biostudies-arrayexpress

Transcriptional analysis of putamen in Parkinson's disease

Project description:Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects Published work contains more information on Parkinson and Control groups

2010-03-23 | E-GEOD-20291 | biostudies-arrayexpress

Transcriptional analysis of whole substantia nigra in Parkinson's disease

2010-03-23 | E-GEOD-20292 | biostudies-arrayexpress

Transcriptional analysis of prefrontal area 9 in Parkinson's disease

2010-02-22 | E-GEOD-20168 | biostudies-arrayexpress

Transcriptional analysis of putamen in Parkinson's disease

Project description:Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

2010-03-12 | GSE20291 | GEO

Transcriptional analysis of whole substantia nigra in Parkinson's disease

Project description:Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

2010-03-12 | GSE20292 | GEO

Transcriptional analysis of prefrontal area 9 in Parkinson's disease

Project description:Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

2010-02-04 | GSE20168 | GEO

CAGE transcriptomes on EBV transformed lymphoblastoid cell lines from central European individuals

Project description:We hypothesized that mapping genetic variants associated with promoter and enhancer functions can provide novel insights into the mechanism through which eQTLs (expression quantitative trait loci) exert their effects on gene expression. To this end, we quantified genome-wide promoter usage and enhancer activity and tested the resulting molecular phenotypes for association with nearby genetic variants to discover cis-QTLs. To perform such analyzes, we have produced deep transcriptome profiling of 154 unrelated central European individuals, applying deepCAGE (Cap Analysis of Gene Expression) to nuclear enriched total RNA extracted from EBV transformed lymphoblastoid cell lines (LCLs). The LCLs were either purchased from Coriell Cell Repository (CEU, n=86) or from the GenCord collection (n=68, Gutierrez-Arcelus M et al. Elife 2013).

2017-09-15 | E-MTAB-5835 | biostudies-arrayexpress

NINDS Parkinson's Disease

Project description:This study utilized the well characterized collection of North American Caucasians with Parkinson's disease, and neurologically normal controls from the sample population which are banked in the National Institute of Neurological Disorders and Stroke (NINDS Repository) collection. Two sub-studies are included, in sub-study NINDS-Genome-Wide Genotyping in Parkinson's Disease, genome-wide, single nucleotide polymorphism (SNP) genotyping of these publicly available samples was originally done in 267 Parkinson's disease patients and 270 controls, and this has been extended to include genome wide genotyping in 939 Parkinson's disease cases and 802 controls; in sub-study NINDS-Exome Sequencing in Parkinson's Disease, genome wide exome DNA sequencing was done in 618 Parkinson's disease samples deposited in Coriell NINDS repository. The DNA comes from a mixture of blood, and from cell lines (lymphoblast cell lines) derived from blood. The GWAS data and exome sequencing data was generated and provided by the laboratory of Neurogenetics lead by Dr. Andrew Singleton, NIA, and Dr. John Hardy, a former chief at NIA, NIH. The NINDS Parkinson's Disease Cohort study is utilized in the following dbGaP individual studies. To view genotypes, whole exome sequencing, and derived variables collected in these individual studies, please click on the following individual studies below or in the "Sub-studies" box located on the right hand side of this top-level study page <a href="study.cgi?study_id=phs001172">phs001172</a> NINDS Parkinson's Disease Cohort study. <ul> <li><a href="study.cgi?study_id=phs000089">phs000089</a> PD GWAS</li> <li><a href="study.cgi?study_id=phs001103">phs001103</a> PD Exome</li> </ul>

| phs001172 | dbGaP

RNA-seq of brain tissue from Parkinson's disease patients [coding exome RNA-seq]

Project description:High throughput sequencing of coding exome RNA from cingylate gyrus brain tissue obtained from control- and Parkinson´s disease patients. In the Parkinson´s disease affected tissue, changes are present that are known to be related to the pathogenesis of neurodegenerative diseases.

2018-10-08 | GSE110716 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data