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Single-cell Transcriptomic Architecture Reveals Dynamic Heterogeneity and Intracellular Crosstalk Features Which Triggers Liver Mallory-Denk Bodies Pathogenesis

ABSTRACT: Liver cell injury causes balloon hepatocytes and Mallory-Denk Bodies (MDBs) formation impeding liver parenchymal regeneration. MDBs are an intracellular deposition of misfolded protein and typical features of distinct chronic liver disease. Therefore, a comprehensive understanding of cellular heterogeneity and intercellular signaling of MDBs formation is essential to elucidate the mechanisms driving MDBs formation and chronic liver disease progression and to develop therapeutic approaches.

ORGANISM(S): Mus musculus

PROVIDER: GSE201569 | GEO | 2023/06/21

REPOSITORIES: GEO

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