Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression
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ABSTRACT: We show that humans with lasting PASC olfactory loss harbor cellular and molecular changes in the olfactory epithelium, the peripheral organ for smell. Biopsy analyses using single cell RNA-sequencing, obtained from 6 patients 4-16 months following infection, identified a dysruption of olfactory epithelium homeostasis with infiltration of unique immune cell populations.
ORGANISM(S): Homo sapiens
PROVIDER: GSE201620 | GEO | 2022/12/21
REPOSITORIES: GEO
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