Dataset Information

Olfactory proteomics in amyotrophic lateral sclerosis

ABSTRACT: Despite smell impairment has been considered a potential non-motor finding in ALS, the pathobiochemistry at olfactory level remains unknown. Here, we applied an olfactory quantitative proteotyping approach to analyze the magnitude of the olfactory bulb (OB) proteostatic imbalance in ALS subjects (n=12) respect to controls (n=8).

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Amyotrophic Lateral Sclerosis

SUBMITTER: Enrique SantamarÃa

LAB HEAD: Enrique Santamaria

PROVIDER: PXD021630 | Pride | 2021-09-09

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	OxidationMSites.txt	Txt
	QUIQUE_ALS1220_190116_001.raw	Raw
	QUIQUE_ALS1240_190116_001.raw	Raw
	QUIQUE_ALS1283_190116_001.raw	Raw
	QUIQUE_ALS1303_190116_001.raw	Raw

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Publications

Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis.

Lachén-Montes Mercedes M Mendizuri Naroa N Ausin Karina K Andrés-Benito Pol P Ferrer Isidro I Fernández-Irigoyen Joaquín J Santamaría Enrique E

International journal of molecular sciences 20201105 21

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis during disease progression. Despite smell impairment being considered a potential non-motor finding in ALS, the pathobiochemistry at the olfactory level remains unknown. Here, we applied an olfactory quantitative proteotyping approach to analyze the magnitude of the olfactory bu ...[more]

PMID: 33167591

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