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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domain [ChIP-seq]

ABSTRACT: Clr3-Myc occupancy along fission yeast chromosomes.

ORGANISM(S): Schizosaccharomyces pombe

PROVIDER: GSE201803 | GEO | 2022/07/12

REPOSITORIES: GEO

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains [Clr3-CDx2]

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains [H3-T7 ChIP]

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains [H3K9me3 ChIP]

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains

Project description:This SuperSeries is composed of the SubSeries listed below.

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains [Clr3-CDx2]

Project description:Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains [Clr3-CDx2]

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domain [ChIP-seq]

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains

Project description:Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains

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Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains [H3K9me3 ChIP]

Project description:Histone deacetylation primes chromatin to preserve epigenetic memory for self-propagation of heterochromatin domains [H3K9me3 ChIP]

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Histone deacetylation promotes transcriptional silencing at facultative heterochromatin

Project description:It is important to accurately regulate the expression of genes involved in development and environmental response. In the fission yeast Schizosaccharomyces pombe, meiotic genes are tightly repressed during vegetative growth. Despite being embedded in heterochromatin these genes are transcribed and believed to be repressed primarily at the level of RNA. However, the mechanism of facultative heterochromatin formation and the interplay with transcription regulation is not understood. We show genome-wide that HDAC-dependent histone deacetylation is a major determinant in transcriptional silencing of facultative heterochromatin domains. Indeed, mutation of class I/II HDACs leads to increased transcription of meiotic genes and accumulation of their mRNAs. Mechanistic dissection of the pho1 gene where, in response to phosphate, transient facultative heterochromatin is established by overlapping lncRNA transcription shows that the Clr3 HDAC contributes to silencing independently of SHREC, but in an lncRNA-dependent manner. We propose that HDACs promote facultative heterochromatin by establishing alternative transcriptional silencing.

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