Other

Dataset Information

0

Genome-wide gain-of-function screening characterized lncRNAs as tumor immune response regulators [CRISPR_screen]


ABSTRACT: The majority of lncRNAs’ roles in tumor immunology remain elusive. In this project, we performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells co-culturing with human CD8+ T cells. We identified 16 novel lncRNAs potentially regulating tumor immune response. Further integrative analysis using tumor immunogenomics data revealed that IL10RB-DT and LINC01198 are significantly correlated with tumor immune response and survival in melanoma and breast cancer. Specifically, IL10RB-DT suppresses CD8+ T cells activation via inhibiting IFN-γ-JAK-STAT1 signaling and antigen presentation in melanoma and breast cancer cells. On the other hand, LINC01198’s upregulation sensitizes the killing of tumor cells by CD8+ T cells. Mechanistically, LINC01198 interacts and activates NF-κB component p65 to trigger the type I and type II interferon responses in melanoma and breast cancer cells. Our study systematically characterized novel lncRNAs involved in tumor immune response. 

ORGANISM(S): Homo sapiens

PROVIDER: GSE202130 | GEO | 2022/12/12

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-09-02 | BIOMD0000000761 | BioModels
2014-08-22 | GSE55070 | GEO
2022-05-30 | PXD029489 | Pride
2014-08-22 | E-GEOD-55070 | biostudies-arrayexpress
2022-05-05 | GSE202151 | GEO
2024-09-05 | PXD055094 | Pride
2013-12-31 | E-GEOD-42824 | biostudies-arrayexpress
2013-01-03 | E-GEOD-43260 | biostudies-arrayexpress
2008-10-25 | E-GEOD-12627 | biostudies-arrayexpress
2016-07-27 | E-GEOD-80736 | biostudies-arrayexpress