Proteomics

Dataset Information

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ChIRP-MS dataset generated from Prohibitin 2 orchestrating transcription of long noncoding RNA and coding gene to accelerate tumorigenesis


ABSTRACT: The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely understood. Here, we show that Prohibitin 2 (PHB2) orchestrates the transcription of an oncogenic CASC15-New-Isoform 2 (CANT2) lncRNA and the coding tumor-suppressor gene CCBE1, thereby accelerating melanoma tumorigenesis. In melanoma cells, to further capture the binding proteins of CANT2, ChIRP-MS was performed.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: He Zhang  

LAB HEAD: He Zhang

PROVIDER: PXD055094 | Pride | 2024-09-05

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
A375KO_CANT1-proSummary.txt Txt
A375NC_CANT1-proSummary.txt Txt
A375NC_Ctrl-proSummary.txt Txt
A375NC_U2-proSummary.txt Txt
Rawdata.tar.gz Other
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