ChIRP-MS dataset generated from Prohibitin 2 orchestrating transcription of long noncoding RNA and coding gene to accelerate tumorigenesis
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ABSTRACT: The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely understood. Here, we show that Prohibitin 2 (PHB2) orchestrates the transcription of an oncogenic CASC15-New-Isoform 2 (CANT2) lncRNA and the coding tumor-suppressor gene CCBE1, thereby accelerating melanoma tumorigenesis. In melanoma cells, to further capture the binding proteins of CANT2, ChIRP-MS was performed.
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: He Zhang
LAB HEAD: He Zhang
PROVIDER: PXD055094 | Pride | 2024-09-05
REPOSITORIES: Pride
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