Transcriptomics

Dataset Information

0

Transcriptomic analysis of TCF-7 cKO CD8 T cells


ABSTRACT: T Cell Factor-1, encoded by TCF-7, is a transcription factor that plays an essential role during T cell development and differentiation. In this manuscript we utilized a pre-clinical model provided evidence that TCF-7 is dispensable for the anti-tumor response, and that TCF-7 suppresses key transcriptional factors Eomes and T-bet and molecules responsible for peripheral CD8 T cell cytolytic function. We discovered that TCF-7 regulates NKG2D expression on naïve and activated mouse CD8 T cells, and that peripheral CD8 T cells from TCF-7 cKO utilize NKG2D to clear tumor cells. We also provide evidence that TCF-7 regulates key signaling molecules, including LCK, LAT, ITK, PLC-y1, P65, ERKI/II, and JAK/STATs required for peripheral CD8 T cell persistent function. Our data transcriptomic and protein data uncovered the mechanism of how TCF-7 impacting peripheral CD8 T cell inflammatory cytokine production, CD8 T cell activation, and apoptosis. Our pre-clinical model showed that CD8 T cells from TCF-7 cKO mice did not cause GVHD, but effectively cleared primary tumor cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE203167 | GEO | 2022/06/30

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-10-01 | GSE182028 | GEO
2014-08-17 | E-GEOD-45657 | biostudies-arrayexpress
| PRJNA838947 | ENA
2021-08-13 | GSE165612 | GEO
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
2014-08-17 | GSE45657 | GEO
2010-10-04 | GSE20754 | GEO
2020-12-04 | GSE159542 | GEO
2024-01-05 | GSE252556 | GEO
2022-11-30 | GSE209743 | GEO