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Gene expression profiling of filaggrin-insufficient keratinocytes exposed to inflammatory mediators and allergens

ABSTRACT: Loss-of-function mutations in the filaggrin gene are heavily associated with the incidence and severity of atopic dermatitis. Moreover, filaggrin insufficiency in epidermal keratinocytes can lead to persistent allergic inflammation and an associated immune response suggesting a role for this protein in regulation of immunity. Here, we investigate how filaggrin insufficiency affects the gene expression pattern in a filaggrin-insufficient (shFLG) keratinocyte cell line HaCaT in response to stimulation with various inflammatory mediators and allergens.

ORGANISM(S): Homo sapiens

PROVIDER: GSE203409 | GEO | 2022/05/20

REPOSITORIES: GEO

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