Genomics

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Study of TUT tailing on miRNA (Endogenous and AGO-IP)


ABSTRACT: Many microRNAs (miRNAs) exist alongside abundant miRNA isoforms (isomiRs), most of which arise from post-maturation sequence modifications, such as 3’ uridylation and adenylation. However, the ways in which these sequence modifications affect miRNA function remain poorly understood. To this aim, we have generated knock-out cell lines of TUT4, TUT7 and TENT2 (TUT2), and obtained miRNA profiles from total RNA, AGO1, and AGO2 immunoprecipitations. Here, using these different cell lines, we have discovered that some of the redundant functions and specific functions of each tailing enzyme. Our study provides a comprehensive characterization of tailing on miRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE203472 | GEO | 2022/08/15

REPOSITORIES: GEO

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