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Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE204874 | GEO | 2022/09/20

REPOSITORIES: GEO

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Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [MeDIP]

Project description:To investigate the associated with abnormal DNA demethylation and neural tube defects (NTDs) with folate deficiency, we etablished mouse embryonic stem cells (mESCs) Sv/129 in folate-deficiency-treated.

2022-09-20 | GSE204872 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [hMeDIP]

2022-09-20 | GSE204870 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [RNA-seq]

Project description:To investigate the associated with the levels of DNA demethylation and neural tube defects (NTDs) with folate deficiency, we etablished mouse embryonic stem cells (mESCs) Sv/129 in folate-deficiency-treated. We then performed gene expression profiling analysis using data obtained from RNA-seq of the cell model.

2022-09-20 | GSE204871 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [ChIP-seq]

Project description:To investigate the associated with DNA demethylation and neural tube defects (NTDs) with folate deficiency, we etablished mouse embryonic stem cells (mESCs) Sv/129 in folate-deficiency-treated.

2022-09-20 | GSE204869 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects

| PRJNA842651 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [MeDIP]

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [MeDIP]

| PRJNA842657 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [hMeDIP]

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [hMeDIP]

| PRJNA842659 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [RNA-seq]

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [RNA-seq]

| PRJNA842658 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [ChIP-seq]

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [ChIP-seq]

| PRJNA842662 | ENA

Neural Tube Defects and Folate Deficiency: Is DNA Repair Defective?

Project description:Neural tube defects (NTDs) are complex congenital malformations resulting from failure of neural tube closure during embryogenesis, which is affected by the interaction of genetic and environmental factors. It is well known that folate deficiency increases the incidence of NTDs; however, the underlying mechanism remains unclear. Folate deficiency not only causes DNA hypomethylation, but also blocks the synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP) and increases uracil misincorporation, resulting in genomic instabilities such as base mismatch, DNA breakage, and even chromosome aberration. DNA repair pathways are essential for ensuring normal DNA synthesis, genomic stability and integrity during embryonic neural development. Genomic instability or lack of DNA repair has been implicated in risk of development of NTDs. Here, we reviewed the relationship between folate deficiency, DNA repair pathways and NTDs so as to reveal the role and significance of DNA repair system in the pathogenesis of NTDs and better understand the pathogenesis of NTDs.

| S-EPMC9916799 | biostudies-literature

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