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Recycling of H2A-H2B provides short-term memory of chromatin states

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE204988 | GEO | 2023/02/06

REPOSITORIES: GEO

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Recycling of H2A-H2B provides short-term memory of chromatin states [ChIP-Seq]

Project description:Chromatin landscapes are disrupted during DNA replication and must be restored faithfully to maintain genome regulation and cell identity. The H3-H4 modification landscape is restored by parental histone recycling and post-replication modification of new histone H3-H4. How DNA replication impact on histone H2A-H2B is unknown. Here, we track H2A-H2B modifications and H2A.Z during DNA replication and across the cell cycle using quantitative genomics. We show that H2AK119ub, H2BK120ub, and H2A.Z are recycled quantitatively and accurately during DNA replication. H2A-H2B are recycled symmetrically to daughter strands largely independent of known H3-H4 recycling pathways. Post-replication, H2A-H2B modifications are rapidly restored, and the rapid wave of H2AK119ub supports accurate restoration of H3K27me3. This work reveals epigenetic transmission of H2A-H2B modification during DNA replication and identifies H3-H4 and H2A-H2B crosstalk in epigenome propagation. We propose that rapid short-term memory of recycled H2A-H2B modifications facilitates reestablishment of slow, long-term chromatin state memory.

2023-02-06 | GSE204974 | GEO

Recycling of H2A-H2B provides short-term memory of chromatin states [SCAR-Seq]

2023-02-06 | GSE204984 | GEO

Recycling of H2A-H2B provides short-term memory of chromatin states [ChOR-Seq]

2023-02-06 | GSE204981 | GEO

Recycling of Histones H2A-H2B provides short-term memory of chromatin states [SCAR-seq II]

Project description:Chromatin landscapes are disrupted during DNA replication and need to be restored faithfully to maintain appropriate gene expression, including post-translational modifications (PTMs) of newly deposited histones. Whether histones H2A-H2B are accurately recycled during DNA replication and the behaviour of their associated marks during and post replication is unknown. Here we comprehensively map key modifications on H2A-H2B including H2A.Z during DNA replication. We show that H2AK119ub, H2BK120ub, and H2A.Z are recycled quantitatively and accurately during DNA replication in a symmetrical manner. Recycling occurs independently from H3-H4 chaperone pathways apart from a minor role for Polymerase alpha. H2A-H2B modifications are restored rapidly post replication and are important for timely and accurate restoration of H3-H4 marks, such as H3K27me3. This work uncovers H3-H4 and H2A-H2B crosstalk in epigenome propagation across DNA replication and suggests a model where rapid short-term memory of recycled H2A-H2B marks facilitates reestablishment of slow, long-term memory chromatin states.

2023-02-06 | GSE222928 | GEO

Recycling of H2A-H2B provides short-term memory of chromatin states

Project description:Recycling of H2A-H2B provides short-term memory of chromatin states

| PRJNA843043 | ENA

Recycling of H2A-H2B provides short-term memory of chromatin states [ChIP-Seq]

Project description:Recycling of H2A-H2B provides short-term memory of chromatin states [ChIP-Seq]

| PRJNA842931 | ENA

Recycling of H2A-H2B provides short-term memory of chromatin states [ChOR-Seq]

Project description:Recycling of H2A-H2B provides short-term memory of chromatin states [ChOR-Seq]

| PRJNA843045 | ENA

Recycling of H2A-H2B provides short-term memory of chromatin states [SCAR-Seq]

Project description:Recycling of H2A-H2B provides short-term memory of chromatin states [SCAR-Seq]

| PRJNA843044 | ENA

Recycling of Histones H2A-H2B provides short-term memory of chromatin states [SCAR-seq II]

Project description:Recycling of Histones H2A-H2B provides short-term memory of chromatin states [SCAR-seq II]

| PRJNA924041 | ENA

Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities.

Project description:ATP-dependent chromatin remodeling activities function to manipulate chromatin structure during gene regulation. One of the ways in which they do this is by altering the positions of nucleosomes along DNA. Here we provide support for the ability of these complexes to move nucleosomes into positions in which DNA is unraveled from one edge. This is expected to result in the loss of histone-DNA contacts that are important for retention of one H2A/H2B dimer within the nucleosome. Consistent with this we find that several chromatin remodeling complexes are capable of catalyzing the exchange of H2A/H2B dimers between chromatin fragments in an ATP-dependent reaction. This provides eukaryotes with additional means by which they may manipulate chromatin structure.

| S-EPMC3428624 | biostudies-literature

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