Transcriptomics

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BET bromodomain inhibition rescues PD-1-mediated T cell exhaustion in acute myeloid leukemia


ABSTRACT: We report that the bromodomain and extraterminal domain (BET) inhibitor JQ1 inhibits PD-1 expression in Jurkat T cells, primary T cells, and a T cell exhaustion model. Furthermore, JQ1 dramatically impaired the expression of PD-1 and T cell immunoglobulin mucin-domain-containing-3 (Tim-3), and promoted the secretion of cytokines in T cells from patients with acute myeloid leukemia (AML).

ORGANISM(S): Homo sapiens

PROVIDER: GSE205605 | GEO | 2022/08/16

REPOSITORIES: GEO

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