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Brain Region-Specific Gene expression in Exercise for a Mouse Model of Parkinson's Disease

ABSTRACT: Exercise plays an essential role in improving motor symptoms in Parkinson’s disease (PD), but the mechanism in the central nervous system remains obscure. We tested effects of 12-week treadmill exercise on a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD and observed a significant improvement in motor ability. Here we performed RNA-sequencing on 4 brain regions from control animals, MPTP-induced PD mice and MPTP-induced PD mice treated with exercise for 12 weeks.

ORGANISM(S): Mus

PROVIDER: GSE205907 | GEO | 2022/07/13

REPOSITORIES: GEO

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