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Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury

ABSTRACT: To explore the impact of targeting IL-10 signaling, tibialis anterior (TA) VML injuries were created and then treated in Sprague Dawley rats using an autologous minced muscle regenerative medicine repair strategy in combination with delayed exogenous IL-10 delivery. We then performed gene expression profiling analysis using data obtained from RNA-seq from rat muscles (n=4 for IL-10 treatment, n=4 for PBS control , and n=4 for uninjured control) at day 14 post injury

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE206823 | GEO | 2022/06/26

REPOSITORIES: GEO

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Transcriptome profiling of the early response to volumetric muscle loss repair strategies

Project description:We report the transcriptomic profiles of rat tibialis anterior following VML injury and three repair strategies in the early period following injury

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