Transcriptomics

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Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease


ABSTRACT: Whole blood samples were collected from patients at baseline, 6 weeks and 8 weeks after induction (Ustekinumab or placebo) therapies for RNA extraction and microarray analysis from patients with moderate-to-severe CD who participated in stelara CD phase 3 studies (UNITI-2). These patients failed conventional therapies previously and largely naive to anti-TNF therapy. We used microarrays to detail the transcriptional programme underlying placebo and stelara treatment in the periphery at WK0, WK6, WK8.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207465 | GEO | 2022/11/08

REPOSITORIES: GEO

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