Transcriptomics

Dataset Information

0

Single-cell transcriptomics of chimeric antigen receptor (CAR) T cell infusion products


ABSTRACT: Adoptive immunotherapy with T cells expressing chimeric antigen receptors (CARs) for B-cell malignancies serves as a model for identifying subsets with superior clinical activity. We profiled the infusion products (IP) of 9 patients with large B-cell lymphoma (LBCL) using scRNA-sequencing to reveal the therapeutic potential of CD19-specific CAR+ T cells. ScRNA-seq demonstrated that T cells from responders were enriched in pathways related to T-cell killing, migration and actin cytoskeleton, and TCR clustering.

ORGANISM(S): Homo sapiens

PROVIDER: GSE208052 | GEO | 2023/03/12

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-02-29 | GSE253872 | GEO
2015-01-14 | E-GEOD-64914 | biostudies-arrayexpress
2015-04-09 | E-GEOD-65856 | biostudies-arrayexpress
| EGAS00001004576 | EGA
2020-07-28 | GSE151511 | GEO
2024-08-12 | GSE273170 | GEO
2018-07-31 | GSE112566 | GEO
2018-07-31 | GSE111641 | GEO
2020-07-28 | GSE150992 | GEO
2021-07-13 | GSE179767 | GEO