Transcriptomics

Dataset Information

0

Identification of a clinically efficacious CAR T cell subset by dynamic multi-dimensional single-cell profiling


ABSTRACT: Adoptive immunotherapy with T cells expressing chimeric antigen receptors (CARs) for B-cell malignancies serves as a model for identifying subsets with superior clinical activity. We profiled the infusion products (IP) of 9 patients with large B-cell lymphoma (LBCL) using scRNA-sequencing to reveal the therapeutic potential of CD19-specific CAR+ T cells. ScRNA-seq demonstrated that T cells from responders were enriched in pathways related to T-cell killing, migration and actin cytoskeleton, and TCR clustering.

ORGANISM(S): Homo sapiens

PROVIDER: GSE253872 | GEO | 2024/02/29

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-03-12 | GSE208052 | GEO
2015-01-14 | E-GEOD-64914 | biostudies-arrayexpress
2022-10-31 | MTBLS5381 | MetaboLights
2024-08-12 | GSE273170 | GEO
2015-04-09 | E-GEOD-65856 | biostudies-arrayexpress
2019-11-07 | PXD007085 | Pride
2018-07-31 | GSE112566 | GEO
2018-07-31 | GSE111641 | GEO
2023-05-02 | GSE231311 | GEO
2023-05-02 | GSE231310 | GEO