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Transcriptional profiling of developing rat ovary following intrauterine exposure to known endocrine disruptors

ABSTRACT: The main objective of the FREIA project is to identify markers of endocrine disrupting effects in rodents to overcome the lack of sensitive markers of female reproductive toxicity. For that 2 archetypes of endocrine disruption are studied, ketoconazole (KTZ) and diethylstilbestrol (DES) at three different stages (post-natal days 6, 14, and 22) and at three different doses 3, 6 and 12 milligram per kilogram by bodyweight per day for KTZ and 3, 6 and 12 microgram per kilogram for DES.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE208545 | GEO | 2023/03/08

REPOSITORIES: GEO

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Transcriptomic analysis of the pre-optic area and the mediobasal hypothalamus of female rats after perinatal exposure to ketoconazole or diethylstylbestrol

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