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Hepatic gene expression profiling reveals key pathways involved in leptin mediated weight loss in ob/ob mice.

ABSTRACT: The purpose of this study was to identify leptin target genes and subsequent pathways correlated with leptin-mediated weight loss. We utilized the microarray technology to compare two types of leptin administration: one involving a direct stimulatory effect when administered peripherally (subcutaneous: SQ) and another that is indirect, involving a hypothalamic relay that suppresses food intake when leptin is administered centrally (intracerebroventricular: ICV). We report here the impact of central and peripheral administration of leptin on food intake, body weight and body fat composition in ob/ob mice. We also report hepatic gene expression changes caused by central versus peripheral leptin administration. Keywords: comparison

ORGANISM(S): Mus musculus

PROVIDER: GSE20878 | GEO | 2010/11/10

SECONDARY ACCESSION(S): PRJNA124675

REPOSITORIES: GEO

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Hepatic gene expression profiling reveals key pathways involved in leptin mediated weight loss in ob/ob mice.

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