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Agilent Mouse liver gene expression profiling of Cross B6/J x A/J

ABSTRACT: Mapping the genetic architecture of RNA transcript abundances has potential for revealing molecular mechanisms underlying complex traits like disease. Gene expression microarrays allow monitoring genetic control on a whole transcriptome level, but validity and reproducibility of microarray data is a subject of ongoing scientific debate. Here we demonstrate how combining genetic and gene expression data provide a basis for biologically relevant assessment of the current state of microarray technology. We profile liver samples from a murine F2 intercross population using Agilent microarrays.

ORGANISM(S): Mus musculus

PROVIDER: GSE20901 | GEO | 2011/02/02

SECONDARY ACCESSION(S): PRJNA129651

REPOSITORIES: GEO

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Agilent Mouse liver gene expression profiling of Cross B6/J x A/J

Project description:Mapping the genetic architecture of RNA transcript abundances has potential for revealing molecular mechanisms underlying complex traits like disease. Gene expression microarrays allow monitoring genetic control on a whole transcriptome level, but validity and reproducibility of microarray data is a subject of ongoing scientific debate. Here we demonstrate how combining genetic and gene expression data provide a basis for biologically relevant assessment of the current state of microarray technology. We profile liver samples from a murine F2 intercross population using Agilent microarrays. Tissue profiling in a mouse F2 cross. We analyzed 298 Liver samples.

2011-02-02 | E-GEOD-20901 | biostudies-arrayexpress

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