Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Serum response factor reduces gene expression noise and confers cell state stability (scRNA-Seq)

ABSTRACT: To explore whether SRF controls cell state heterogeneity, SRF KO or wild type (WT) iPSCs cultured in serum containing medium.

ORGANISM(S): Mus musculus

PROVIDER: GSE210073 | GEO | 2023/01/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Serum response factor reduces gene expression noise and confers cell state stability (Bulk RNA-Seq)

Project description:To explore whether SRF controls cell state heterogeneity, SRF KO or wild type (WT) iPSCs cultured in serum containing medium.

2023-01-01 | GSE210072 | GEO

Serum response factor reduces gene expression noise and confers cell state stability

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-01 | GSE210074 | GEO

Serum response factor reduces gene expression noise and confers cell state stability (scRNA-Seq)

Project description:Serum response factor reduces gene expression noise and confers cell state stability (scRNA-Seq)

| PRJNA863617 | ENA

Serum response factor reduces gene expression noise and confers cell state stability

Project description:Serum response factor reduces gene expression noise and confers cell state stability

| PRJNA863612 | ENA

Serum response factor reduces gene expression noise and confers cell state stability (Bulk RNA-Seq)

Project description:Serum response factor reduces gene expression noise and confers cell state stability (Bulk RNA-Seq)

| PRJNA863618 | ENA

Gene expression of normal and ASCC1-mutant skin fibroblasts after serum starvation and serum challenge

Project description:In order to investigate the genes that might be regulated by the activating signal cointegrator 1 (ASC-1) complex we performed an expression analysis using the GeneChip® Human Gene 2.0 ST Array (Affymetrix) Since ASC-1 was predicted to have an influence on the transcription regulation by the serum response factor (SRF), we investigated gene expression after serum starvation and subsequent serum challenge.

2015-10-01 | GSE67627 | GEO

Transcription profiling of mouse Serum response factor (Srf) conditional knockout in the mouse liver

Project description:Serum response factor (SRF) is a transcription factor that binds to the serum response element (SRE) of genes that are expressed in response to mitogens. SRF plays essential roles in muscle and nervous system development; however, little is known about the role of SRF during liver growth and function. To examine the function of SRF in the liver, we generated mice in which the Srf gene was specifically disrupted in hepatocytes. The survival of mice lacking hepatic SRF activity was lower than that of control mice; moreover, surviving mutant mice were smaller and had lower blood glucose and triglyceride levels compared with control mice. Srf-deficient livers were also smaller than control livers, hepatocyte morphology was abnormal, and liver-cell proliferation and viability was compromised. Gene array and quantitative RT-PCR analysis of SRF depleted livers revealed a reduction in mRNAs encoding components of the growth hormone/IGF1 pathway, cyclins, several metabolic regulators, and cytochrome p450 enzymes. Conclusion: SRF is essential for hepatocyte proliferation and survival, liver function, and control of postnatal body growth by regulating hepatocyte gene expression. Experiment Overall Design: Total RNA was harvested from the following sources and used for Affymetrix array analysis following manufacturer defined protocols: Experiment Overall Design: control liver (Srf loxP/+ AlfpCre): 3 male mice (3 weeks old) Experiment Overall Design: mutant liver (Srf loxP/loxP AlfpCre): 3 male mice (3 weeks old), tissue used lacked Srf

2009-03-07 | E-GEOD-13333 | biostudies-arrayexpress

Serum Response Factor binding in Dstn-corn1 mutant and WT murine cornea

Project description:We report the application of chromatin immunoprecipitation sequencing to identify binding sites of the transcription factor serum response factor (SRF) in the cornea of WT and Dstn-corn1 mutant mice Examination of SRF binding sites in WT and Dstn-corn1 mutant cornea

2014-01-18 | E-GEOD-54209 | biostudies-arrayexpress

Early effects of Serum Response Factor (SRF) gene deletion on the vascular gene expression

Project description:The objective of this study is to assess the early effects of the Serum Response Factor deletion on the vascular gene expression program. To generate smooth muscle specific SRF knockout, 4 month-old [SRF-flex2neo -SM22CreERT2ki/+] mice (SRFSMKO mice) were injected i.p. with 1mg of tamoxifen for 3 days. All control (SRF-flex2neo littermates) and SRFSMKO mice were systematically injected with tamoxifen to normalize for any effects due to tamoxifen.

2014-12-31 | GSE34545 | GEO

The influence of the deletion of Serum Response Factor in B cells

Project description:Serum response factor (SRF), a MADS-box transcription factor, is essential for murine embryonic development and for the function of muscle cells and neurons. SRF and its transcriptional co-factors are broadly expressed. To determine the in vivo role of SRF in developing lymphocytes we specifically inactivated the murine Srf gene during T or B cell development using lymphocyte-specific Cre transgenic mouse lines. T cell-specific Srf deletion led to a severe block in thymocyte development at the transition from double to single positive stage. The few residual T cells detectable in the periphery retained at least one functional Srf allele, thereby demonstrating the importance of SRF in T cell development. In contrast, deletion of Srf in developing B cells did not interfere with the growth and survival of B cells in general, yet led to a complete loss of marginal zone B cells and a marked reduction of the CD5+ B cell subset. Our study also revealed a contribution of SRF to the expression of the surface molecules IgM, CD19, and the chemokine receptor 4 in B lymphocytes. Keywords: Genetic modification

2007-06-27 | GSE7412 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data