Transcriptomics

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Runx1 Controls Auditory Sensory Neuron Diversity (CKO)


ABSTRACT: As the primary sensory neurons of the auditory system, Type I spiral ganglion neurons (SGNs) encode sound stimulus properties critical for the formation of auditory percept in higher brain areas. Their functional heterogeneity is thought to contribute to our ability to hear a wide range of sound intensities and against background noise, but how SGN diversity arises during development is poorly understood. Here we studied the role of the transcription factor Runx1 in establishing SGN heterogeneity in the mouse cochlea by single cell RNA-sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE210215 | GEO | 2023/01/13

REPOSITORIES: GEO

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