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Single-nuclei profiling of chromatin accessibility and transcriptomes of jaw mesenchymal cells in wild-type and nr5a2 mutant zebrafish embryos

ABSTRACT: The functional jaw is composed of multiple connective tissues including skeletal components (bone, cartilage, and teeth), tendon, ligament, and musculature. Cranial neural crest-derived mesenchyme of the mandibular arch give rise to diverse tissue types within the lower jaw. To understand how the specification of diverse cell types with spatial and temporal precision is achieved, we profile multi-omic chromatin accessibility (snATACseq) and transcriptome (snRNAseq) of jaw mesenchyme at single-cell resolution from the developing zebrafish jaw.

ORGANISM(S): Danio rerio

PROVIDER: GSE210251 | GEO | 2023/02/13

REPOSITORIES: GEO

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