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Gene expression profiles of islets of Langerhans isolated from 7 weeks wt and Wnt4 conditional knock outs.

ABSTRACT: To check the role of Wnt4 in murine β cells function, we inactivated Wnt4 in β cells from 4-5 weeks using tamoxifen. After 2 weeks tamoxifen treatment, we collected islets from control and mutant mice. We found that Wnt4 knock out islets show significant reduction of oxidation-reduction processes, cysteine and methionine metabolism, fatty acid beta-oxidation and fatty acid biosynthesis, as well as transport mechanisms. On the contrary, ribosome related genes, as well as oxidative stress and apoptosis genes were up-regulated.

ORGANISM(S): Mus musculus

PROVIDER: GSE210267 | GEO | 2022/08/04

REPOSITORIES: GEO

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