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M6A modification in DP and iNKT cells

ABSTRACT: Invariant natural killer T (iNKT) cells are a specific innate-like counterpart of T lymphocytes, which response to lipid-based antigens and provide a functional bridge between the innate and adaptive immunity. The physiological role of m6A modification involved in NK cells differentiation remains unclear. We found that N6-Methyladenosine (m6A) methyltransferase METTL3 is intrinsically required for iNKT cell development and function in an m6A-dependent manner. To investigate the molecular mechanisms, m6A-LACE-seq was performed using iNKT cells and Merip-seq was performed using DP cells in thymocytes isolated from WT and KO mice to investigate the regulatory network.

ORGANISM(S): Mus musculus

PROVIDER: GSE210325 | GEO | 2023/12/31

REPOSITORIES: GEO

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m6A modification in DP and iNKT cells

Project description:m6A modification in DP and iNKT cells

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