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Methylation analysis of patients with COVID-19 and Clonal Hematopoiesis

ABSTRACT: Coronavirus disease 2019 (COVID-19) is associated with significant morbidity and mortality, albeit with considerable heterogeneity among affected individuals. Emerging evidence points towards an important role of preexisting host factors, such as a deregulated inflammatory response at the time of infection. Here, we demonstrate the negative impact of clonal hematopoiesis, a prevalent clonal disorder of ageing individuals, on COVID-19-related cytokine release severity and mortality. In this study we perform use the Illumina MethylationEPIC array to quantify methylation levels in PBMCs from COVID19 patients and patients with clonal hematopoiesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210430 | GEO | 2024/08/14

REPOSITORIES: GEO

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