Transcriptomics

Dataset Information

0

TET2 Mutant Clonal Hematopoiesis Enhances Severity of COVID-19 Related Cytokine Release Syndrome and is Associated with Increased Mortality [scMULT]


ABSTRACT: Coronavirus disease 2019 (COVID-19) is associated with significant morbidity and mortality, albeit with considerable heterogeneity among affected individuals. Emerging evidence points towards an important role of preexisting host factors, such as a deregulated inflammatory response at the time of infection. Here, we demonstrate the negative impact of clonal hematopoiesis, a prevalent clonal disorder of ageing individuals, on COVID-19-related cytokine release severity and mortality. In this study we perform Multiome single cell sequencing of PBMCs from COVID19 patients and patients with clonal hematopoiesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210432 | GEO | 2024/08/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-14 | GSE210433 | GEO
2024-08-14 | GSE210430 | GEO
2024-08-14 | GSE210782 | GEO
2024-08-14 | GSE211379 | GEO
| PRJNA865718 | ENA
| PRJNA870071 | ENA
2021-12-08 | GSE180578 | GEO
2024-12-05 | GSE264196 | GEO
2024-08-28 | GSE264189 | GEO
| PRJNA865722 | ENA