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NFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation

ABSTRACT: Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function.

ORGANISM(S): Mus musculus

PROVIDER: GSE21063 | GEO | 2011/03/24

SECONDARY ACCESSION(S): PRJNA126753

REPOSITORIES: GEO

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NFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation

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