Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human blastoid

ABSTRACT: Based on our previous works, we established an optimized protocol that enables the generation of blastocyst-like structures from human pluripotent stem cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210961 | GEO | 2023/08/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Generation of blastocyst-like structures from human embryonic stem cells I [scRNA-seq]

Project description:We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.

2021-01-24 | GSE150570 | GEO

Generation of blastocyst-like structures from human embryonic stem cells III [scRNA-seq]

Project description:We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.

2021-01-24 | GSE163445 | GEO

Generation of blastocyst-like structures from human embryonic stem cells II [scRNA-seq]

Project description:We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.

2021-01-24 | GSE163423 | GEO

Generation of human blastocyst-like structures from pluripotent stem cells

Project description:Generation of human blastocyst-like structures from pluripotent stem cells

| PRJEB44768 | ENA

Generation of Blastocyst-like Structures from Extended Pluripotent Stem Cells

Project description:Generation of Blastocyst-like Structures from Extended Pluripotent Stem Cells

| PRJNA558254 | ENA

Generation of human blastocyst-like structures from pluripotent stem cells

Project description:Generation of human blastocyst-like structures from pluripotent stem cells

| PRJNA667174 | ENA

Generation of human blastocyst-like structures from pluripotent stem cells

Project description:Generation of human blastocyst-like structures from pluripotent stem cells

| PRJNA727994 | ENA

Human blastoid from primed human incuded pluripotent stem cells

Project description:A human blastoid, which is an artificial human blastocyst, and has a potential as great tool to investigate fundamentals during the development and establish in vitro models to study the pregnancy failure and birth deficiency, without the use of a human embryo. In 2021, although some methods to generate blastoids have been reported, they used human naïve pluripotent stem cells, which often show genomic instability during in vitro culture. Here, we introduce the simple, robust and scalable method to generate human blastoids from more stable human primed pluripotent stem cells. By using non-cell-adhesive hydrogel, hPSC aggregates received the chemophysical cellular environment, and forming the asymmetric blastoid structure with the cellular distribution like a human blastocyst. The obtained blastoids also showed the capability the implantation in vitro. This model will enable to elucidate the underlying mechanisms of human pre- and post-implantation process, leading to assisted reproductive technology.

2024-06-29 | GSE231683 | GEO

Human blastoid from primed human embryonic stem cells

Project description:A human blastoid, which is an artificial human blastocyst, and has a potential as great tool to investigate fundamentals during the development and establish in vitro models to study the pregnancy failure and birth deficiency, without the use of a human embryo. In 2021, although some methods to generate blastoids have been reported, they used human naïve pluripotent stem cells, which often show genomic instability during in vitro culture. Here, we introduce the simple, robust and scalable method to generate human blastoids from more stable human primed embryonic stem cells. By using non-cell-adhesive hydrogel, hESC aggregates received the chemophysical cellular environment, and forming the asymmetric blastoid structure with the cellular distribution like a human blastocyst. The obtained blastoids also showed the capability the implantation in vitro. This model will enable to elucidate the underlying mechanisms of human pre- and post-implantation process, leading to assisted reproductive technology.

2024-06-29 | GSE231484 | GEO

Human blastoid from primed human embryonic stem cells

Project description:A human blastoid, which is an artificial human blastocyst, and has a potential as great tool to investigate fundamentals during the development and establish in vitro models to study the pregnancy failure and birth deficiency, without the use of a human embryo. In 2021, although some methods to generate blastoids have been reported, they used human naïve pluripotent stem cells, which often show genomic instability during in vitro culture. Here, we introduce the simple, robust and scalable method to generate human blastoids from more stable human primed embryonic stem cells. By using non-cell-adhesive hydrogel, hESC aggregates received the chemophysical cellular environment, and forming the asymmetric blastoid structure with the cellular distribution like a human blastocyst. The obtained blastoids also showed the capability the implantation in vitro. This model will enable to elucidate the underlying mechanisms of human pre- and post-implantation process, leading to assisted reproductive technology.

2024-06-29 | GSE206469 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data