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AAV9-medated cardiac expression of lncRNA CARDINAL ameliorate TAC induced hypertrophy

ABSTRACT: Pathological cardiac hypertrophy is featured by enhanced protein synthesis. Translation inhibition is effective in treating cardiac hypertrophy, yet with systematic side effect. We identified a cardiac-enriched LncRNA CARDINAL, when over-expressed in cardiomyocyte using AAV9 driven by cTNT promoter, ameliorate transaortic constriction (TAC) induced hypertrophy.

ORGANISM(S): Mus musculus

PROVIDER: GSE210983 | GEO | 2024/04/22

REPOSITORIES: GEO

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AAV9-medated cardiac expression of lncRNA CARDINAL ameliorate TAC induced hypertrophy

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