Transcriptional profiling of striatum in METH self-administered rats [miRNA]
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ABSTRACT: This study aimed to identify changes in novel miRNAs and their target genes during METH self-administration and investigate their roles in METH-induced locomotion. RNA sequencing analysis revealed that mir-183-5p was upregulated in the striatum of METH self-administered rats, and target gene prediction revealed that the glucocorticoid receptor (GR) gene, Nr3c1, was a potential target gene for mir-183-5p. We confirmed that single and repeated METH administrations increased METH-induced locomotion and plasma corticosterone levels in rats.
ORGANISM(S): Rattus norvegicus
PROVIDER: GSE211185 | GEO | 2022/10/19
REPOSITORIES: GEO
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