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Transcriptional profiling of striatum in METH self-administered rats

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE211186 | GEO | 2022/10/19

REPOSITORIES: GEO

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Transcriptional profiling of striatum in METH self-administered rats [miRNA]

Project description:This study aimed to identify changes in novel miRNAs and their target genes during METH self-administration and investigate their roles in METH-induced locomotion. RNA sequencing analysis revealed that mir-183-5p was upregulated in the striatum of METH self-administered rats, and target gene prediction revealed that the glucocorticoid receptor (GR) gene, Nr3c1, was a potential target gene for mir-183-5p. We confirmed that single and repeated METH administrations increased METH-induced locomotion and plasma corticosterone levels in rats.

2022-10-19 | GSE211185 | GEO

Transcriptional profiling of striatum in METH self-administered rats [mRNA]

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Transcriptional profiling of striatum in METH self-administered rats

Project description:Transcriptional profiling of striatum in METH self-administered rats

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Transcriptional profiling of striatum in METH self-administered rats [mRNA]

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Transcriptional Profiling of Whisker Follicles and of the Striatum in Methamphetamine Self-Administered Rats.

Project description:Methamphetamine (MA) use disorder is a chronic neuropsychiatric disease characterized by recurrent binge episodes, intervals of abstinence, and relapses to MA use. Therefore, identification of the key genes and pathways involved is important for improving the diagnosis and treatment of this disorder. In this study, high-throughput RNA sequencing was performed to find the key genes and examine the comparability of gene expression between whisker follicles and the striatum of rats following MA self-administration. A total of 253 and 87 differentially expressed genes (DEGs) were identified in whisker follicles and the striatum, respectively. Multivariate and network analyses were performed on these DEGs to find hub genes and key pathways within the constructed network. A total of 129 and 49 genes were finally selected from the DEG sets of whisker follicles and of the striatum. Statistically significant DEGs were found to belong to the classes of genes involved in nicotine addiction, cocaine addiction, and amphetamine addiction in the striatum as well as in Parkinson's, Huntington's, and Alzheimer's diseases in whisker follicles. Of note, several genes and pathways including retrograde endocannabinoid signaling and the synaptic vesicle cycle pathway were common between the two tissues. Therefore, this study provides the first data on gene expression levels in whisker follicles and in the striatum in relation to MA reward and thereby may accelerate the research on the whisker follicle as an alternative source of biomarkers for the diagnosis of MA use disorder.

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Transcriptional profiling of whisker follicles and of the striatum in methamphetamine self-administered rats

Project description:This study provides the first data on gene expression levels in whisker follicles and in the striatum in relation to MA reward and thereby may accelerate the research on the whisker follicle as an alternative source of biomarkers for the diagnosis of MA use disorder.

2021-08-27 | GSE157112 | GEO

Transcriptional profiling reveals differential changes in the expression of oxytocin and CARTpt mRNAs in the nucleus accumbens and dorsal striatum of rats

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-09-26 | GSE95571 | GEO

Transcriptome profiling of whisker follicles in methamphetamine self-administered rats.

Project description:Methamphetamine (MA) is a highly addictive psychostimulant that disturbs the central nervous system; therefore, diagnosis of MA addiction is important in clinical and forensic toxicology. In this study, a MA self-administration rat model was used to illustrate the gene expression profiling of the rewarding effect caused by MA. RNA-sequencing was performed to examine changes in gene expression in rat whisker follicles collected before self-administration, after MA self-administration, and after withdrawal sessions. We identified six distinct groups of genes, with statistically significant expression patterns. By constructing the functional association network of these genes and performing the subsequent topological analysis, we identified 43 genes, which have the potential to regulate MA reward and addiction. The gene pathways were then analysed using the Reactome and Knowledgebase for Addiction-Related Gene database, and it was found that genes and pathways associated with Alzheimer's disease and the heparan sulfate biosynthesis were enriched in MA self-administration rats. The findings suggest that changes of the genes identified in rat whisker follicles may be useful indicators of the rewarding effect of MA. Further studies are needed to provide a comprehensive understanding of MA addiction.

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Transcriptional profiling of whisker follicles and of the striatum in methamphetamine self-administered rats

Project description:Transcriptional profiling of whisker follicles and of the striatum in methamphetamine self-administered rats

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Transcriptome profiling in knock-in mouse models of Huntington's disease [striatum; cortex; liver; tissue survey]

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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