Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Angiotensin II Increases Oxidative Stress and Inflammation in Female, But Not Male, Endothelial Cells

ABSTRACT: To investigate sex differences in endothelial cell response to AngII, male and female human umbilical vein endothelial cells (HUVEC) were treated with AngII for 24 hours. RNA seq was run, and demonstrated that female HUVEC had elevated genes associated with oxidative stress and inflammatory responses compared to male HUVEC following AngII treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE211978 | GEO | 2023/03/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Sex-specific transcriptional differences between non-treated male and female human umbilical vein endothelial cells (HUVEC)

Project description:Significant sex differences exist in cardiovascular diseases. It is largely unknown whether sexually dimorphic gene expression plays a role, and whether cells themselves show intrinsic sex differences. We therefore performed whole genome expression analyses in human umbilical vein endothelial cells (HUVEC) from five sample pools with equal amounts of four individual RNAs from either male or female donors (altogether 20 male and 20 female donors) and compared levels of gene transcription between the sexes. Genes indicative for greater immune responsiveness were stronger expressed in female compared to male HUVEC. There was a significant enrichment of 77 immune-related genes in female HUVEC.

2014-12-31 | GSE52212 | GEO

Human Endothelial Cell Secretome

Project description:Endothelial cell secretomes were analyzed using culture medium derived from control young and premature senescent human umbilical vein endothelial cell (HUVEC).

2020-01-29 | PXD016932 | Pride

Kaposi’s Sarcoma-associated Herpesvirus Viral Protein Kinase Augments Cell Survival

Project description:Human umbilical vein endothelial cells (HUVECs) expressing vPK (HUVEC-vPK) have a survival advantage over control HUVEC under conditions of extrinsic- and intrinsic-mediated apoptosis.

2023-09-16 | GSE241970 | GEO

Rubella Virus wildtype and vaccine strains induce transcription of chemokines and components of innate immunity in human embryonic endothelial cells

Project description:We describe the transcriptional response to infection of human umbilical vein endothelial cells (Huvec) with different rubella virus strains

2022-08-31 | GSE192648 | GEO

Leukotriene D4-triggered Transcriptome

Project description:Human umbilical vein endothelial cells (HUVEC) or the human macrophage cell line, Mono-Mac-6, treated with Leukotriene D4 for 1 hour Keywords = Leukotriene-Transcriptome Keywords = Mono-Mac-6 Keywords = HUVEC Keywords: other

2004-08-20 | GSE1644 | GEO

Regulation of oxidative stress in endothelial cells exposed to high glucose by selected microRNA

Project description:Hyperglycemia is the hallmark of diabetes mellitus that results in oxidative stress, endothelial dysfunction and vascular complications of diabetes. MicroRNAs (miRNAs) play a role in the development of endothelial dysfunction in diabetes, with potential application for the future therapy of diabetic vascular complications. However, there is a limited number of studies that characterize the miRNA profile of endothelial cells exposed to hyperglycemic condition. This study aimed to identify the miRNA profile of human umbilical vein endothelial cells (HUVEC) exposed to hyperglycemic state using RNA sequencing analysis.

2023-07-06 | GSE229207 | GEO

OncomiR-21 triggers growth arrest of endothelial cells via a complex network involving p21 CDK2 CDC25A and NFIB

Project description:miRNA transcription in senescent human umbilical vein endothelial cells (HUVEC) compared to young HUVECs.

2013-01-17 | E-MEXP-3596 | biostudies-arrayexpress

miRNA in HUVEC culture supernatant

Project description:Human umbilical vein endothelial cells (HUVEC) were cultured in serum-free medium with 50 μmol/L ADMA (ADMA group) or without ADMA (NA group ). Asymmetric dimethylarginine is a typical uremic toxin which used to induce HUVEC injury.

2022-07-05 | GSE207436 | GEO

DHA effect on endothelial cells (HUVEC) under proinflammatory condition

Project description:Transcriptional profiling of Human Umbilical Vein Endothelial Cells (HUVEC) comparing untreated control cells with IL-1-treated cells with or without pre-treatment with DHA.

2015-05-20 | GSE57825 | GEO

siRNA-mediated Egr-3 knockdown in VEGF-treated HUVEC

Project description:Analysis of umbilical vein endothelial cells (HUVEC) treated with Egr-3 siRNA under the VEGF treatment for 0,1, and 4 h. Egr-3, a member of early growth response family, is immediately and dramatically induced by VEGF in HUVEC, which regulates expression of many genes related to endothelial activation.

2009-11-30 | GSE18913 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data