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CD8+ T lymphocytes in hypopigmented mycosis fungoides: malignant cells or reactive clone?

ABSTRACT: We used targeted single cell RNA sequencing using a gene set composed of the BD Rhapsody Human Immune Response Panel, TCR panel, and a custom panel of 61 malignancy-associated genes and T/B cell receptor sequencing to characterize single cell populations in hypopigmented mycosis fungoides (HMF). Using a reference mapping model built on publically deposited classic mycosis fungoides single cell RNA sequencing datasets, we identified a predicted malignant cell population independent from the clonal T cell population in HMF.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212146 | GEO | 2023/10/17

REPOSITORIES: GEO

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