Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of IL-13 on primary esophageal fibroblasts

ABSTRACT: This is part of a larger experiment in which the effects of IL-13, LIGHT and TGF-B1 on human primary esophageal fibroblasts were analyzed and compared.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212731 | GEO | 2022/09/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

IL-13 Stimulated Esophageal Epithelial miRNA

Project description:miRNA profiling of unstimulated and IL-13 stimulated esophageal epithelial cells

2012-06-26 | E-MEXP-3351 | biostudies-arrayexpress

Comparison of the LIGHT and TGF-B1 induced transcriptomes in esophageal FBL

Project description:To understand the transcriptional responses induced by LIGHT in esophageal fibroblasts and compare them to the pro-fibrotic TGF-B1

2020-08-03 | GSE143482 | GEO

IL-13 miR-375 Esophageal Epithelial Cell

Project description:Expression profiling of Control transduced and Pre-miR-375 transduced esophageal epithelial cells stimulated with or without IL-13

2012-06-27 | E-MEXP-3345 | biostudies-arrayexpress

PIR-B negatively regulates IL-13-induced esophageal eosinophil effector functions

Project description:Eosinophilic esophagitis (EoE) is a T helper type 2 (TH2) cytokine-associated disease charaterized by eosinophil infiltration, epithelial cell hyperplasia and tissue remodeling. Recent studies have highlighted a major contribution for IL-13 in EoE pathogenesis. Paired immunoglobulin-like receptor (PIR)-B is a cell surface immune-inhibitory receptor that is expressed by eosinophils and postulated to regulate eosinophil development and migration. We report that Pirb is upregulated in the esophagus after inducible overexpression of IL-13 (CC10-IL13 Tg mice) and is overexpressed by esophageal eosinophils. CC10-IL13Tg/PirB-/- mice displayed increased esophageal eosinophilia and EoE pahtology, including epithelial cell thickening, fibrosis and angiogenesis, compared with CC10-IL13 Tg/PirB+/+ mice. Transcriptome analysis of primary Pirb+/+ and Prib-/- esophageal eosinophils revealed increased expression of transcripts associated with promoting tissue remodeling in Pirb-/- eosinophils including pro-fibrotic genes, genes promoting epithelial-to-mesenchymal transition (EMT) and genes associated with epithelial growth. These data identify PIR-B as a molecular checkpoint in IL-13-induced eosinophil accumulation and activation, which may serve as a novel target for future therapy in EoE.

2016-05-05 | GSE81135 | GEO

Comparison of the LIGHT and TGF-B1 induced transcriptomes in esophageal FBL

Project description:Comparison of the LIGHT and TGF-B1 induced transcriptomes in esophageal FBL

| PRJNA600741 | ENA

Effect of IL-13 and Vitamin D treatment on gene expression and epigenetics in the esophageal epithelial cell line EPC2

Project description:We report RNA- and ChIP-sequencing profiling of the esophageal epithelial cell line EPC2 in response to IL-13 and Vitamin D either alone or in the combined treatment

2022-03-22 | GSE184868 | GEO

IL-13 involvement in eosinophilic esophagitis: transcriptome analysis

Project description:3 eosinophilic esophagitis biopsies, cultured and stimulated with IL-13 : each of them was either left unstimulated or stimulated (100ng for 48h) We used microarray to uncover the IL-13-induced genes in esophageal epithelial cells of the esophagus Keywords: treated vs non treated

2007-12-21 | GSE8853 | GEO

Transcription profiling of human eosinophilic esophagitis biopsies, cultured and stimulated with IL-13

Project description:3 eosinophilic esophagitis biopsies, cultured and stimulated with IL-13 : each of them was either left unstimulated or stimulated (100ng for 48h); We used microarray to uncover the IL-13-induced genes in esophageal epithelial cells of the esophagus Experiment Overall Design: 3 biopsies from EE patients were obtained and primary epithelial cell were cultured and either left unstimulated or stimulated with IL-13 followed by RNA extraction and hybridization on Affymetrix microarrays.

2008-06-20 | E-GEOD-8853 | biostudies-arrayexpress

IMR90 lung fibroblasts treated with IL-4 or IL-13

Project description:IL-4 and IL-13 are cytokines involved in type 2 immune responses involved in atopic asthma and other diseases. They have a partially overlapping set of cognate receptors whose roles are incompletely understood. Here we explore the effects of these cytokines on lung fibroblasts in order to assess the global similarities and contrasts in the genes whose expression their ligation modulates. IMR-90 lung fibroblast cells were cultured on matrigel or plastic and treated for 24 hours with IL-4 (10 ng/ml), IL-13 (10ng/ml), or TNFa (10 ng/ml) before harvest.

2013-12-31 | E-GEOD-47542 | biostudies-arrayexpress

IMR90 lung fibroblasts treated with IL-4 or IL-13

2013-12-31 | GSE47542 | GEO