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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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IL-13 Stimulated Esophageal Epithelial miRNA

ABSTRACT: miRNA profiling of unstimulated and IL-13 stimulated esophageal epithelial cells

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Lu

PROVIDER: E-MEXP-3351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MiR-375 is downregulated in epithelial cells after IL-13 stimulation and regulates an IL-13-induced epithelial transcriptome.

Lu T X TX Lim E-J EJ Wen T T Plassard A J AJ Hogan S P SP Martin L J LJ Aronow B J BJ Rothenberg M E ME

Mucosal immunology 20120328 4

Interleukin 13 (IL-13)-induced epithelial gene and protein expression changes are central to the pathogenesis of multiple allergic diseases. Herein, using human esophageal squamous and bronchial columnar epithelial cells, we identified microRNAs (miRNAs) that were differentially regulated after IL-13 stimulation. Among the IL-13-regulated miRNAs, miR-375 showed a conserved pattern of downregulation. Furthermore, miR-375 was downregulated in the lung of IL-13 lung transgenic mice. We subsequently ...[more]

PMID: 22453679

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