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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 [ChIP-Seq 2]

ABSTRACT: Genome-wide mapping of histone modification H3R17me2a in neonatal cardiomyocyte

ORGANISM(S): Mus musculus

PROVIDER: GSE212982 | GEO | 2023/12/26

REPOSITORIES: GEO

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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ChIP-Seq)

Project description:Genome-wide mapping of histone modification H3R17me2a in neonatal hearts

2023-12-26 | GSE197195 | GEO

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 [RNA-Seq 2]

Project description:Transcriptome profile of Carm1 KO and Wildtype neonatal heart cardiomyocyte

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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (RNA-Seq)

Project description:Genome-wide transcriptome analysis of the neonatal control and Carm1 mutant hearts

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Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ATAC-Seq)

Project description:Analysis of genome-wide chromatin accessibility of the neonatal control and Carm1 mutant hearts

2023-12-26 | GSE197194 | GEO

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-26 | GSE197197 | GEO

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1

| PRJNA809345 | ENA

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ChIP-Seq)

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ChIP-Seq)

| PRJNA809350 | ENA

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (RNA-Seq)

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (RNA-Seq)

| PRJNA809349 | ENA

Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ATAC-Seq)

Project description:Epigenetic regulation of cardiac maturation by arginine methyltransferase Carm1 (ATAC-Seq)

| PRJNA809351 | ENA

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification.

Project description:BackgroundChondrogenesis and subsequent endochondral ossification are processes tightly regulated by the transcription factor Sox9 (SRY-related high mobility group-Box gene 9), but molecular mechanisms underlying this activity remain unclear. Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9.ResultsCARM1-null mice display delayed endochondral ossification and decreased chondrocyte proliferation. Conversely, cartilage development of CARM1 transgenic mice was accelerated. CARM1 specifically methylates Sox9 at its HMG domain in vivo and in vitro. Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes.ConclusionThese results establish a role for CARM1 as an important regulator of chondrocyte proliferation during embryogenesis.

| S-EPMC2754437 | biostudies-literature

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