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Impact of Tle3 deficiency on memory T cell chromatin accessbility landscape

ABSTRACT: The goal of this study is to determine if central memory (Tcm) and effector memory (Tem) CD8 T cells can be reprogrammed to change their fate. We demonstrate that genetic ablation of Tle3 can promote generation of Tcm cells at the expense of Tem cells, and this can occur during the effector phase of the immune response.

ORGANISM(S): Mus musculus

PROVIDER: GSE213035 | GEO | 2023/10/10

REPOSITORIES: GEO

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Impact of Tle3 deficiency on memory T cell transcriptome

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