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Dosage compensation of Z sex chromosome genes in avian fibroblast cells

ABSTRACT: Sex in birds is genetically determined, molecular mechanism of which is not well-understood. Their Z sex chromosome (chrZ) lacks whole chromosome inactivation as known for mammalian chrX. To investigate the extent of chrZ dosage compensation and its role in somatic cell’s sex specification, we used a highly-quantitative method and analyzed transcriptional activities of male and female fibroblasts from seven birds. Our data indicate for the first time that ¾ of chrZ genes are strictly compensated, similar to that observed in chrX. We also describe non-compensated chrZ genes and identify Ribosomal Protein S6 (RPS6) as a candidate for universal, sex-dimorphic genes in birds.

ORGANISM(S): Coturnix japonica Meleagris gallopavo Pavo cristatus Gallus gallus Anas platyrhynchos Taeniopygia guttata Dromaius novaehollandiae

PROVIDER: GSE213253 | GEO | 2023/08/30

REPOSITORIES: GEO

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