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Siponimod ameliorates metabolic injury via the sphingosine1 phospohate receptor 5

ABSTRACT: we followed the hypothesis that Siponimod, a sphingosine-1 phosphate receptor modulator exerts protective effects by a direct modulation of glia cell function

ORGANISM(S): Mus musculus

PROVIDER: GSE213374 | GEO | 2022/09/17

REPOSITORIES: GEO

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Altered gene expression in the neocortices and hippocampi of the adult S1P2-deficient and S1P3-deficient mice

Project description:Altered gene expression in the sphingosine 1-phosphate receptor 2 (S1P2)-deficient or sphingosine 1-phosphate receptor 3 (S1P3)-deficient brain. Keywords: genetic modification

2007-03-09 | GSE7191 | GEO

Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [heart]

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Transcription profiling of mouse neocortices and hippocampi from adult S1P2-deficient and S1P3-deficient mice

Project description:Altered gene expression in the sphingosine 1-phosphate receptor 2 (S1P2)-deficient or sphingosine 1-phosphate receptor 3 (S1P3)-deficient brain. Experiment Overall Design: The S1P2-deficient mice suffer from spontaneous/sporadic seizures during 4-7 weeks of age. The S1P3 deficient mice do not show such seizures. The 8-week-old mice were sacrificed for sample preparation. Neocortices and hippocampi were isolated from wild-type, S1P2-deficient, and S1P2-deficient mice (n=10, 5, and 10, respectively).

2008-06-15 | E-GEOD-7191 | biostudies-arrayexpress

Title: Elevated SGPL1 expression increases metabolic rate and reduces survival in adrenocortical carcinoma patients

Project description:Sphingosine-1-phosphate lyase (SGPL1) catalyses the final step in sphingolipid metabolism (Figure 1), irreversibly degrading the lipid signalling molecule sphingosine-1-phosphate (S1P). Loss-of-function mutations in SGPL1 cause a spectrum of disorders, including primary adrenal insufficiency. Given loss of SGPL1 causes reduced steroidogenesis, while increased steroidogenesis is a hallmark of aggressive adrenocortical carcinomas (ACCs), we hypothesise increased SGPL1 expression might regulate ACCs. We identified a potential novel biomarker in ACCs, whereby increased SGPL1 expression correlates with reduced patient survival. We also saw similar correlation with other sphingolipid enzymes which diminish the ceramide pool, while those that replenish it confer a beneficial patient outcome. Increased SGPL1 expression in a cell model increased their resting proliferation and migration, although no effect on apoptosis was seen. There was a global decrease in the sphingolipid pool, possibly indicating increased flux through this pathway. RNAseq analysis identified an increase in expression of oxidative phosphorylation genes, and this correlated with an increase in basal and maximal glycolysis and oxidative phosphorylation. Finally, we showed that the increase in proliferation in the OE cells is dependent on the presence of metabolic substrates which may be used for anabolism and/or the production of ATP.

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The phosphorylated prodrug FTY720 is a histone deacetylase Q15 inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

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