Transcriptomics

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The phosphorylated prodrug FTY720 is a histone deacetylase Q15 inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer


ABSTRACT: Nuclear FTY720-P is a potent inhibitor of class I histone deacetylases (HDACs) that enhances histone acetylations and regulates expression of a restricted set of genes independently of its known effects on canonical signaling through sphingosine-1-phosphate (S1P) receptors. We found that FTY720 is phosphorylated in Era-negative breast cancer cells by nuclear sphingosine kinase 2 and accumulates these cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69462 | GEO | 2015/06/03

SECONDARY ACCESSION(S): PRJNA285668

REPOSITORIES: GEO

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