Genomics

Dataset Information

0

Refined read-out: hUHRF1‑tandem Tudor prefers histone H3 containing K9me2/3 and K4me1


ABSTRACT: Histone post-translational modifications (PTMs) are an important part of chromatin signaling mechanisms. Among them, histone H3 has a prominent role, and combinations of multiple PTMs are common. We investigated binding of multiple marks on the same H3 histone by the human UHRF1-TTD (Uniprot Q96T88, residues 126-280), known to bind H3K9me2/3 histones. We verified binding to H3K9me2/3 and demonstrated stronger binding to synthetic H3 peptides containing K4me1 and K9me2/3 as well as native HepG2 mononucleosomes bearing both H3K9me2/3 and H3K4me1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE213741 | GEO | 2023/08/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-07-30 | E-MTAB-4982 | biostudies-arrayexpress
2012-07-31 | E-GEOD-39579 | biostudies-arrayexpress
2016-06-01 | PXD003709 | Pride
2012-05-31 | E-GEOD-36397 | biostudies-arrayexpress
2012-07-30 | E-GEOD-39580 | biostudies-arrayexpress
2015-11-05 | E-GEOD-66318 | biostudies-arrayexpress
2014-09-24 | E-GEOD-56053 | biostudies-arrayexpress
2017-10-09 | PXD007582 | Pride
2012-07-31 | GSE39580 | GEO
2012-07-31 | GSE39579 | GEO