The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells
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ABSTRACT: To help advancing cancer immunotherapies, we developed a step-wise CRISPR knockout (KO) screening strategy under the selection of TGF-beta, and identified Cul5 as a core negative-feedback regulator of CD8+ T cell differentiation and persistence.
ORGANISM(S): Mus musculus
PROVIDER: GSE213921 | GEO | 2023/09/01
REPOSITORIES: GEO
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