Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [Nanostring]

ABSTRACT: Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer. SOX11 and its epigenetic regulators can be developed as prognostic markers for DCIS patients with recurrence risk independent of traditional clinical and pathologic characteristics.

ORGANISM(S): Homo sapiens

PROVIDER: GSE214093 | GEO | 2024/07/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [ATAC-seq]

Project description:Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer. SOX11 and its epigenetic regulators can be developed as prognostic markers for DCIS patients with recurrence risk independent of traditional clinical and pathologic characteristics.

2024-07-17 | GSE213977 | GEO

Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [Nanostring]

Project description:Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [Nanostring]

| PRJNA883756 | ENA

Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer

Project description:Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer

| PRJNA883755 | ENA

RNA-seq of DCIS-pInducer21-SOX11 cells grown in 2D and 3D

Project description:Using the pINDUCER21 system, we modified DCIS.com cells so that SOX11 is expressed at much higher levels after induction with Doxycycline (Dox) than observed with the constitutive DCIS-SOX11 cells we have used to model DCIS progression. After Dox induction of pIND21-SOX11 cells, both SOX11 and CD24 expression are significantly increased ). Higher ALDH levels are detected in pIND21-SOX11 cells, suggesting that high levels of SOX11 promotes acquisition of features associated with distinct types of cancer stem cells.

2020-09-21 | E-MTAB-9108 | biostudies-arrayexpress

Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [ATAC-seq]

Project description:Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [ATAC-seq]

| PRJNA883400 | ENA

Copy number analysis of DCIS with and without recurrence

Project description:We analysed a cohort of pure DCIS cases treated only with wide local excision for genome-wide copy number and loss of heterozygosity using Affymetrix OncoScan® MIP arrays. Cases included those without recurrence within 6 years (n=25) and with recurrence between 1-5 years after diagnosis (n=15). Additional cases were excluded for low grade (n=6) or non-clonal recurrence (n=2). Recurrence tumour was available for 8 cases. Pure DCIS were broadly similar in copy number changes compared to invasive breast cancer, with the consistent exception of a greater frequency of ERBB2 amplification in DCIS. There were no significant differences in age or ER status between the cases with a recurrence versus those without. Overall, the DCIS cases with recurrence had more copy number events than the DCIS without recurrence. The increased copy number appeared non-random with several genomic regions showing an increase in frequency in recurrent cases including 20q gain, ERBB2 amplification and 15q loss. Copy number changes may provide prognostic information for DCIS recurrence but validation in additional cohorts is required.

2015-12-01 | GSE66746 | GEO

cDNA aCGH study of pure DCIS without invasive tumor, DCIS associated with IDC and its IDC component

Project description:cDNA aCGH study of pure DCIS (breast duct carcinoma in situ) without invasive tumor, DCIS associated with IDC (breast invasive duct carcinoma) and its IDC component 23 patients: 6 pure DCIS without invasive cancer and no history of invasive cancer, 17 DCIS associated with IDC. Out of the latter 1 tumor had only enough DCIS (#16) for aCGH and one - IDC (#23) Keywords: Comparative clinical study

2009-02-01 | GSE10197 | GEO

RNA-seq of DCIS-pInducer21-SOX11 cells grown in 2D and 3D

Project description:RNA-seq of DCIS-pInducer21-SOX11 cells grown in 2D and 3D

| PRJEB38439 | ENA

Expression profiling of murine DCIS and invasive ductal breast carcinoma

Project description:Murine healthy tissue samples, DCIS and invasive mammary tumors were analyzed in order to identify marker genes which show enhanced expresssion in DCIS and invasive ductal carcinomas. Using this approach, we were able to identify a set of genes which might allow a better detection of DCIS and invasive carcinomas in the future.

2011-04-11 | GSE21444 | GEO

Expression profiling of human DCIS and invasive ductal breast carcinoma

Project description:Human healthy tissue samples, DCIS and invasive mammary tumors were analyzed in order to identify marker genes which show enhanced expresssion in DCIS and invasive ductal carcinomas. Using this approach, we were able to identify a set of genes which might allow a better detection of DCIS and invasive carcinomas in the future.

2011-04-11 | GSE21422 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data